Elevated Serum Concentrations of Inflammatory and Oxidative Stress Markers In Patients With Preeclampsia
Anahtar Kelimeler:
Preeclampsia, fatty acid binding protein-6, 4-hydroxynonenal, 8-hydroxy-2’deoxyguanosine, neurotrophin-3 and cathelicidinÖzet
Background: This study aimed to investigate serum concentrations of fatty acid binding protein-6 (FABP6), 4-hydroxynonenal (4-HNE), 8-hydroxy-2’deoxyguanosine (8-OHdG), neurotrophin-3 (NTF-3) and cathelicidin (LL-37) in patients with and without preeclampsia.
Methods: A total of 64 women with preeclampsia (32 of whom with severe features of preeclampsia) and 24 normotensive pregnant women were eligible for the study. Clinical and obstetric features and serum levels of FABP6, 4-HNE, 8-OHdG, NTF-3 and LL-37 were evaluated in each subject.
Fındıngs: The study found that serum FABP6, 4-HNE, 8-OHdG, NTF-3, and LL-37 levels were significantly higher in women with pre-eclampsia compared to normotensive pregnant women. Furthermore, subgroup analyses revealed that FABP6 and LL-37 levels were significantly higher in cases of severe pre-eclampsia compared to cases of non-severe pre-eclampsia.
Conclusions: The data of the present study suggested that higher levels of circulating FABP6, 4-HNE, 8-OHdG, NTF-3 and LL-37 are associated with an increased risk of developing preeclampsia and these markers might be involved in preeclampsia pathogenesis.
Referanslar
Akinci, S., Ozcan, H. C., Balat, O., Ugur, M. G., Ozturk, E., & Taysi, S., et al. (2017). Assessment of β-hydroxydeoxyguanosine levels in patients with preeclampsia: A prospective study. Clinical and Experimental Obstetrics & Gynecology, 44(2), 226–229.
American College of Obstetricians and Gynecologists. (2020). Gestational hypertension and preeclampsia: ACOG practice bulletin, number 222. Obstetrics & Gynecology, 135(6), e237–e260. https://doi.org/10.1097/AOG.0000000000003891
Bernd, P. (2008). The role of neurotrophins during early development. Gene Expression, 14(4), 241–250.
Casciaro, A., Arcuri, F., Occhini, R., Toti, M. S., De Felice, C., & Toti, P. (2009). Expression of placental neurotrophin-3 (NT-3) in physiological pregnancy, preeclampsia and chorioamnionitis. Clinical Medicine: Pathology, 2, 9–15. https://doi.org/10.4137/cpath.s2325
Chekir, C., Nakatsuka, M., Noguchi, S., Konishi, H., Kamada, Y., & Sasaki, A., et al. (2006). Accumulation of advanced glycation end products in women with preeclampsia: Possible involvement of placental oxidative and nitrative stress. Placenta, 27(2–3), 225–233. https://doi.org/10.1016/j.placenta.2005.02.016
Chen, X., Zou, X., Qi, G., Tang, Y., Guo, Y., & Si, J., et al. (2018). Roles and mechanisms of human cathelicidin LL-37 in cancer. Cellular Physiology and Biochemistry, 47(3), 1060–1073. https://doi.org/10.1159/000490183
D’Souza, V. A., Kilari, A. S., Joshi, A. A., Mehendale, S. S., & Pisal, H. M., et al. (2014). Differential regulation of brain-derived neurotrophic factor in term and preterm preeclampsia. Reproductive Sciences, 21(2), 230–235. https://doi.org/10.1177/1933719113493512
D’Souza, V., Patil, V., Pisal, H., Randhir, K., Joshi, A., & Mehendale, S., et al. (2014). Levels of brain-derived neurotrophic factors across gestation in women with preeclampsia. International Journal of Developmental Neuroscience, 37, 36–40. https://doi.org/10.1016/j.ijdevneu.2014.06.008
Duggavathi, R., Siddappa, D., Schuermann, Y., Pansera, M., Menard, I. J., & Praslickova, D., et al. (2015). The fatty acid binding protein 6 gene (Fabp6) is expressed in murine granulosa cells and is involved in ovulatory response to superstimulation. Journal of Reproduction and Development, 61(3), 237–240. https://doi.org/10.1262/jrd.2014-139
Ferguson, K. K., Meeker, J. D., McElrath, T. F., Mukherjee, B., & Cantonwine, D. E. (2017). Repeated measures of inflammation and oxidative stress biomarkers in preeclamptic and normotensive pregnancies. American Journal of Obstetrics and Gynecology, 216(5), 527.e1–527.e9. https://doi.org/10.1016/j.ajog.2016.12.174
Hendrick, A. G., Müller, I., Willems, H., Leonard, P. M., Irving, S., Davenport, R., et al. (2016). Identification and investigation of novel binding fragments in the fatty acid binding protein 6 (FABP6). Journal of Medicinal Chemistry, 59(17), 8094–8102. https://doi.org/10.1021/acs.jmedchem.6b00869
Hnat, M. D., Meadows, J. W., Brockman, D. E., Pitzer, B., Lyall, F., & Myatt, L. (2005). Heat shock protein-70 and 4-hydroxy-2-nonenal adducts in human placental villous tissue of normotensive, preeclamptic and intrauterine growth restricted pregnancies. American Journal of Obstetrics and Gynecology, 193(3), 836–840. https://doi.org/10.1016/j.ajog.2005.01.059
Ho, S. S. C., Keenan, J. I., & Day, A. S. (2020). The role of gastrointestinal-related fatty acid-binding proteins as biomarkers in gastrointestinal diseases. Digestive Diseases and Sciences, 65(2), 376–390. https://doi.org/10.1007/s10620-019-05841-x
Kermani, P., & Hempstead, B. (2007). Neurotrophins and cardiovascular development. Trends in Cardiovascular Medicine, 17(4), 140–143. https://doi.org/10.1016/j.tcm.2007.03.002
Kimura, C., Watanabe, K., Iwasaki, A., Mori, T., Matsushita, H., & Shinohara, K., et al. (2013). The severity of hypoxic changes and oxidative DNA damage in the placenta of early-onset preeclamptic women and fetal growth restriction. Journal of Maternal-Fetal & Neonatal Medicine, 26(5), 491–496. https://doi.org/10.3109/14767058.2012.733766
Li, B., Yang, H., Zhang, W., Shi, Y., Qin, S., & Wei, Y., et al. (2018). Fatty acid-binding protein 4 predicts gestational hypertension and preeclampsia in women with gestational diabetes mellitus. PLoS ONE, 13(2), e0192347. https://doi.org/10.1371/journal.pone.0192347
Oliveira-Bravo, M., Sangiorgi, B. B., Schiavinato, J. L., Carvalho, J. L., Covas, D. T., & Panepucci, R. A., et al. (2016). LL-37 boosts immunosuppressive function of placenta-derived mesenchymal stromal cells. Stem Cell Research & Therapy, 7(1), 189. https://doi.org/10.1186/s13287-016-0448-3
Owaki, Y., Watanabe, K., Iwasaki, A., Saitou, T., Matsushita, H., & Wakatsuki, A. (2021). Placental hypoplasia and maternal organic vascular disorder in pregnant women with gestational hypertension and preeclampsia. Journal of Maternal-Fetal & Neonatal Medicine, 34(3), 353–359. https://doi.org/10.1080/14767058.2019.1608175
Perucci, L. O., Vieira, É. L. M., Teixeira, A. L., Gomes, K. B., Dusse, L. M., & Sousa, L. P. (2017). Decreased plasma concentrations of brain-derived neurotrophic factor in preeclampsia. Clinica Chimica Acta, 464, 142–147. https://doi.org/10.1016/j.cca.2016.11.034
Sahay, A. S., Jadhav, A. T., Sundrani, D. P., Wagh, G. N., & Joshi, S. R. (2020). Differential expression of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) in different regions of normal and preeclampsia placentae. Clinical and Experimental Hypertension, 42(4), 360–364. https://doi.org/10.1080/10641963.2019.1665677
Sahay, A. S., Sundrani, D. P., & Joshi, S. R. (2017). Neurotrophins: Role in placental growth and development. Vitamins and Hormones, 104, 243–261. https://doi.org/10.1016/bs.vh.2016.11.002
Sahay, A., Kale, A., & Joshi, S. (2020). Role of neurotrophins in pregnancy and offspring brain development. Neuropeptides, 83, 102075. https://doi.org/10.1016/j.npep.2020.102075
Santoso, D. I., Rogers, P., Wallace, E. M., Manuelpillai, U., Walker, D., & Subakir, S. B. (2002). Localization of indoleamine 2,3-dioxygenase and 4-hydroxynonenal in normal and pre-eclamptic placentae. Placenta, 23(5), 373–379. https://doi.org/10.1053/plac.2002.0818
Takagi, Y., Nikaido, T., Toki, T., Kita, N., Kanai, M., Ashida, T., et al. (2004). Levels of oxidative stress and redox-related molecules in the placenta in preeclampsia and fetal growth restriction. Virchows Archiv, 444(1), 49–55. https://doi.org/10.1007/s00428-003-0903-2
Zhang, Y., Zhao, X., Deng, L., Li, X., Wang, G., & Li, Y., et al. (2019). High expression of FABP4 and FABP6 in patients with colorectal cancer. World Journal of Surgical Oncology, 17(1), 171. https://doi.org/10.1186/s12957-019-1714-5
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